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KMID : 0379520180340030259
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한국독성학회지
2018 Volume.34 No. 3 p.259 ~ p.266
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Genotoxicity Study of Glycopeptide (G-7%NANA)
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Kim Ha-Young
Kim Min-Hee
Kim Hee-Kyong
Park Yeong-Chul
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Abstract
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Glycomacropeptide (GMP), a whey protein of milk, has functions including differentiation and development of nervous system, and anticancer and antiviral effects. To develop new functions, N-acetylneuraminic acid (NANA) containing 7% sialic acid was separated from GMP to produce G-7%NANA. N-glycolylneuraminic acid (Neu5Gc) is another type of sialic acid separated from GMP, which has been linked to immune disorders and chronic inflammation-mediated diseases. Therefore, safety was a concern in the use of G-7%NANA in functional foods. To ensure safety, in this study, three genetic toxicity tests on G-7%NANA were conducted. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli WP2uvrA, and in the chromosome aberration test using CHO-K1 cells, no significant differences from negative control were found at all dose levels. Similarly, no dose-related differences were evident compared to negative control in the micronucleus test using ICR mice. There was no evidence of G-7%NANA-related genetic toxicity.
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KEYWORD
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Glycomacropeptide, N-acetylneuraminic acid, Genetic toxicity test, Sialic acid, N-acetylneuraminic acid
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